Blar i forfatter "Nova, Ainara"
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Computational Studies on the Mechanisms for Deaminative Amide Hydrogenation by Homogeneous Bifunctional Catalysts
Artús Suàrez, Lluís; Balcells, David; Nova, Ainara (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-14)The deaminative hydrogenation of amides is one of the most convenient pathways for the synthesis of amines and alcohols. The ideal source of reducing equivalents for this reaction is molecular hydrogen, though, in practice, this approach requires high pressures and temperatures, with many catalysts achieving only small turnover numbers and frequencies. Nonetheless, during the last ten years, this ... -
Enantioselective incorporation of CO2: status and potential
Vaitla, Janakiram; Guttormsen, Yngve; Mannisto, Jere K.; Nova, Ainara; Repo, Timo; Bayer, Annette; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-09)CO<sub>2</sub> is a promising and sustainable carbon feedstock for organic synthesis. New catalytic protocols for efficient incorporation of CO<sub>2</sub>into organic molecules are continuously being reported. However, little progress has been made in the enantioselective conversion of CO<sub>2</sub>to form enantioenriched molecules. In order to allow CO<sub>2</sub>to become a versatile carbon ... -
A highly asymmetric gold(III) η3‐allyl complex
Holmsen, Marte Sofie; Nova, Ainara; Øien-Ødegaard, Sigurd; Heyn, Richard H.; Tilset, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)A highly asymmetric Au<sup>III</sup> η<sup>3</sup>‐allyl complex has been generated by treating Au(η<sup>1</sup>‐allyl)Br(tpy) (tpy=2‐(<i>p</i>‐tolyl)pyridine) with AgNTf<sub>2</sub>. The resulting η<sup>3</sup>‐allyl complex has been characterized by NMR spectroscopy and X‐ray crystallography. DFT calculations and variable temperature <sup>1</sup>H NMR suggest that the allyl ligand is highly fluxional. -
Rational selection of co-catalysts for the deaminative hydrogenation of amides
Artús Suàrez, Lluís; Jayarathne, Upul; Balcells, David; Bernskoetter, Wesley H.; Hazari, Nilay; Jaraiz, Martin; Nova, Ainara (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-20)The catalytic hydrogenation of amides is an atom economical method to synthesize amines. Previously, it was serendipitously discovered that the combination of a secondary amide co-catalyst with (<sup>iPr</sup>PNP)Fe(H)(CO) (<sup>iPr</sup>PNP = N[CH<sub>2</sub>CH<sub>2</sub>(P<sup>i</sup>Pr<sub>2</sub>)]<sub>2</sub>−), results in a highly active base metal system for deaminative amide hydrogenation. ... -
Synthesis of substituted (N,C) and (N,C,C) Au(iii) complexes: the influence of sterics and electronics on cyclometalation reactions
Hylland, Knut Tormodssønn; Schmidtke, Inga; Wragg, David Stephen; Nova, Ainara; Tilset, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-04)Cyclometalated Au(III) complexes are of interest due to their catalytic, medicinal, and photophysical properties. Herein, we describe the synthesis of derivatives of the type (N,C)Au(OAcF)2 (OAcF = trifluoroacetate) and (N,C,C)AuOAcF by a cyclometalation route, where (N,C) and (N,C,C) are chelating 2-arylpyridine ligands. The scope of the synthesis is explored by substituting the 2-arylpyridine core ...